Development of advanced computational algorithms and tools to assist the design of functional interventions in Parkinson's disease and resistant epilepsy
The surgical treatment of chronic neurological diseases that cannot be adequately treated by medicines is widely applied for two diseases: epilepsy and Parkinson's disease. This project aims at the development of advanced computational algorithms and software tools for the digital processing of brain signals (EEG, microelectrode recordings) and for the computational modelling of brain structures/functions based on individualized anatomical and neurophysiological data. The computational tools that will be developed will mainly aim at the establishment of quantitative features (measures) to assist diagnosis, treatment and evaluation of therapeutic outcome in Parkinson's disease and epilepsy. Furthermore, the applicability of the developed algorithms and computational tools to other neurological/ neuropsychiatric diseases will be investigated.
FP6-IST-4-027333-STP, "Micro2DNA: Integrated polymer-base microfluidic micro system for DNA extraction, amplification, and silicon-based detection"
The project is going to develop a single device integrated micro system for nucleic acid extraction, purification, PCR amplification, reagent mixing, biochemical reactions and finally DNA micro array detection in real time. The technologies combined are silicon-based for the implementation of the DNA micro array detection and polymer-based for the construction of the micro fluidic module. A chip that will be developed in the project will be ideally suited for being integrated in the portable low cost system and will perform the signal transduction, interpretation and data analysis. The aim is to deliver a product targeting to point-of-care applications, with emphasis on providing very rapid and accurate results. The micro system which will be developed will be validated in four different healthcare applications.
Development of a smart insulin infusion system for patients with diabetes, using telematics and embedded GSM and WPAN technologies. Issues relating to the management of medical data of patients with diabetes, processing and development of simulation models of the metabolic glucose-insulin system, combined with the monitoring of blood glucose levels and insulin injection technologies, are the main objects of the project. Particular emphasis is placed on safety during transport, treatment and management of medical patient data.
Implementation of Variance Reduction Techniques for Improvement in Computation Efficiency of GATE Monte Carlo Simulation Package on a Distributed Computing Platform- fastGATE
GATE is a novel openSource toolkit for simulation of full-edged clinical PET and SPECT systems. It allows the user to model realistic nuclear medicine experiments with an easy to use, yet powerful, scripting language. GATE simulations are CPU-bound computations, in the sense that most of the work corresponds to numerical calculations related to particle transport. Thus, realistic imaging simulations, including transmission tomography, usually take weeks or months to complete in state-of-the-art single-CPU computers. However, it is also generally true that Monte Carlo simulations are excellent candidates for embarrassingly parallel solutions to the computational problem, because the amount of interprocess communication is small, and usually only at process start-up and termination. In addition, variance reduction techniques provide execution speed up since a number of physical processes such as photon splitting, electron history repetition etc can improve the efficiency of the simulated code. It is possible to further improve the efficiency by optimizing transport parameters such as electron energy cut-off, maximum electron energy step size, photon energy cut-off, a cut-off for kerma approximation and use of delta scattering technique, without loss of calculation accuracy. The aim of the proposed project is the implementation and application of variance reduction techniques (VRTs) in order to speedup the execution time of the GATE Monte Carlo simulation package on distributed computing platforms and the development of a cluster in BIOSIM.
Design and development of telemedicine services to serve the needs of the inhabitants of the region, focusing on situations of emergency medical care. Services will be based on technologies that enable the collection and transmission of important diagnostic biosignals (ECG, blood pressure, pulse oximetry, temperature), the collection and transmission of video signals or image sequences. Services include diagnosis, medical support in long distances and counseling services in remote medical units (ambulance, rural health centers, provincial doctors, etc.) by specialists at regional hospitals or medical centers.
EMedIT 's main objectives focus upon: i) providing a roadmap of transnational integration into a common framework regarding ICT in the EastMed (EM) region, ii) promoting support services including training to ICT regional authorities and public bodies on an equal basis, iii) discussing relevant ICT issues and iv) fostering the development of ICT, thus reducing the "digital divide" gap in the EastMed. Short term outcomes of EMedIT are the establishment of cooperation and networking between all EM actors involved in ICT and the provision of Support Services and Training Assistance to the regulatory institutions, telecom operators and other relevant bodies in 4 EM countries, while the long term outcomes are the eestablishment of a unified and coherent method of acting, thinking and policy-making on ICT in the region and thus establish concrete benefits for them as well as for the public they serve.
Small animal imaging is a very important research field in order to develop new radiopharmaceuticals for clinical application. Still clinical used devices are not optimised for small animal imaging, where very high spatial resolution and sensitivity is needed. A new generation of compact gamma cameras based on Position Sensitive Photomutiplier Tubes (PSPMTs) offer submillimeter resolution. These detectors are used in small animal imaging since the performance of such cameras meets the need of high resolution and high sensitivity. Such systems find clinical application as well. The most promising field for such a system is scintimammography, where metabolic information is necessary in order to discriminate benign from malicious tumors. Several parameters of imaging with PSPMTs can be studied and optimised, including crystals, collimators, data acquisition and signal and image analysis. ΑThe main objective of the proposed project is the optimization of a dedicated camera suitable for small animal imaging, which is hosted by the Greek part. In terms of this project the Greek and the Albanian team will collaborate in order to exchange knowledge in the field of detector development, crystal simulation and medical imaging. The optimised detector will be assessed using phantoms, small animals and possibly patients.
An Integrated Broadband Telecommunication Pilot Telecervices-platform for Improving Health Care Provision in the Region of Mediterranean - INTERMED
Aim of the proposed project is the design, development and management of a pilot trans-, East-Mediterranean broadband communication platform for the provision of medical services for both citizens and travellers in remote/isolated regions of Mediterranean Sea , and in board ships travelling across it. The services will improve the quality of life and the feeling of safety concerning the health of citizens and travellers in the aforementioned area, through, among others, t ele-collaboration, tele-monitoring, tele-diagnosis, and e learning capabilities.
Line of postgraduate courses of total duration of 60 hours with regard to subjects of electromagnetic compatibility in systems of wireless communications with accent in the systems of mobile communications of 3G (UMTS).