The paper by Gastounioti et al. published in the Special issue on Grand Challenges in Engineering Life Sciences and Medicine of the IEEE Transactions on Biomedical Engineering
The research work of the Biomedical Simulations and Imaging Laboratory of the NTUA (BIOSIM-NTUA)  was selected for publication in the Special issue on Grand Challenges in Engineering Life Sciences and Medicine of the IEEE Transactions on Biomedical Engineering, one of the top 5 among all biomedical engineering journals (source).
The BIOSIM-NTUA work addresses a major clinical challenge, namely valid risk stratification in carotid atherosclerosis, toward prevention of stroke, a serious and frequent cerebrovascular disease with an enormous socioeconomic burden worldwide. Of the 15 million people suffering a stroke annually, 5 million die and another 5 million are left permanently disabled, while stroke care accounts for about 3% of total health care expenditures . With the current decision making procedure for treating carotid atherosclerosis being inadequate and inefficient, the paper elucidates the potential of carotid ultrasound image analysis toward more effective health care planning and allocation of resources. A clinical scenario for optimal management of atherosclerotic patients is described, while challenges and necessary future steps toward its realization are discussed. Advanced methods for the extraction of ultrasound-image-based features are introduced revealing valuable information on plaque composition and stability (Fig. 3 of ). Thus, a low-cost routine ultrasound examination is upgraded into a powerful tool for objective and personalized clinical assessment of patients with carotid atherosclerosis.
 S. Golemati, A. Gastounioti, K.S. Nikita, "Toward novel noninvasive and low-cost markers for predicting strokes in asymptomatic carotid atherosclerosis: the role of ultrasound image analysis," IEEE Trans Biomed Eng, 60 (3), pp. 652-658, 2013.
 World Health Organisation. The Atlas of Heart Disease and Stroke. http://www.who.int/cardiovascular_diseases/resources/atlas/en/.
 S. M. Evers, J. N. Struijs, A. J. Ament, M. L. van Genugten, J. H. Jager, and G. A. M. van den Bos, “International comparison of stroke cost studies,” Stroke, vol. 35, pp. 1209–1215, 2004.
 A.R. Naylor, “Time to rethink management strategies in asymptomatic carotid artery disease,” Nature Rev. Cardiol., vol. 9, no. 2, pp. 116–124, 2011.